Phenotypic expression and genetic heterogeneity of lincosamide inactivation in Staphylococcus spp

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Phenotypic expression and genetic heterogeneity of lincosamide inactivation in Staphylococcus spp.

We examined the resistance phenotype and the genetic basis of lincosamide modification in 25 clinical isolates of Staphylococcus spp. inactivating lincomycin and clindamycin. The strains were resistant to high levels of lincomycin but remained susceptible to clindamycin. However, MBCs and inoculum effects showed that the activity of clindamycin was impaired. The distribution in these strains of...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 1987

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.31.12.1887